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Image Search Results
Journal: International Journal of Nanomedicine
Article Title: Advancements in Nanocarrier Delivery Systems for Photodynamic Therapy in Lung Cancer
doi: 10.2147/IJN.S521444
Figure Lengend Snippet: Illustration of near-infrared region II (NIR-II) photo-accelerated polymer nanoparticle (PPNP) enhancing tumor immunotherapy via Programmed Death-Ligand 1 (PD-L1) silencing and immunogenic cell death (ICD). ( a ) The preparation of PPNP/siRNA. ( b ) Upon activation by 808 nm laser and overexpressed GSH, PPNP/siRNA will undergo cleavage, releasing both the NIR-II PS and siPD-L1. ROS production will be stimulated, leading to tumor ICD, the release of damage-associated molecular patterns (DAMPs), recruitment of T cells to lymph nodes, activation of T cells, and initiation of T cell immune responses. Simultaneously, the released siPD-L1 will inhibit PD-L1 activity on tumor cells, enhance phagocytosis of tumor cells by T cells, activate systemic anti-tumor immune responses, and ultimately reshape the immune microenvironment. This photo-accelerated immunotherapy strategy facilitates tumor-specific immune responses and remodeling of the TME. Reprinted from Zhang T, Tang D, Wu P, et al. NIR-II photo-accelerated polymer nanoparticles boost tumor immunotherapy via PD-L1 silencing andimmunogenic cell death. Bioact Mater . 2025;46:285–300.
Article Snippet: Inorganic
Techniques: Polymer, Activation Assay, Activity Assay